What is the primary concern with metallosis in metal-on-metal hip implants?

• A. Elevated metal ions causing adverse local tissue reaction and systemic effects
• B. Decreased wear resistance
• C. Increased corrosion resistance
• D. Lower cost

Answer: (A)

Metallosis from metal-on-metal hip implants centers on metal ion release. Wear and corrosion of the metal surfaces produce ions (especially cobalt and chromium) that accumulate in the surrounding soft tissues and in the bloodstream. These ions trigger inflammatory and cytotoxic processes, leading to adverse local tissue reactions such as tissue destruction and osteolysis, and in some cases to systemic effects. That makes elevated metal ions causing local damage and potential systemic toxicity the primary concern. The other options miss the core issue: metallosis isn’t about decreased wear resistance, it isn’t about increased corrosion resistance, and cost is not the central risk.